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tennessee technological university

Chemical Engineering

Assistant Professor
Highest Degree University: PhD in Chemical Engineering from the University of California, Santa Barbara
jrice@tntech.edu
PO Box: 5013
(931) 372-3678

Lab website



Research Interest

  • Development of novel therapeutic proteins using combinatorial protein engineering techniques
  • Design of in vitro cellular flow chambers for high-throughput evaluation of therapeutic molecules
  • Generation of bio-synthetic hydrogels using protein/polymeric hybrid systems
  • Rational protein design for more effect protein engineering methodologies

More Information

Jeffrey J. Rice received his Ph.D. in Chemical Engineering from the University of California, Santa Barbara in 2007 where he engineered protein display techniques to discover novel therapeutic peptides. After which he played a major role in transitioning the technology for industrial use as a research scientist at CytomX Therapeutics, Inc. Currently, he is an assistant professor at the Tennessee Technological University carrying out research in the area of protein and biological engineering. Before beginning his faculty position, he was a Whitaker post-doctoral research fellow in the Laboratory for Regenerative Medicine and Pharmacobiology at the École Polytechnique Fédérale de Lausanne working under Professor Jeff Hubbell. His research focuses on applying protein engineering techniques to modify extracellular matrix proteins and growth factors to study angiogenesis and gene delivery for enhanced tissue repair and regeneration.

Education

  • Ph.D. in Chemical Engineering, University of California, Santa Barbara, 2007
    • Thesis: Development & Optimization of Bacterial Display Methodologies for Peptide Library Screening
  • B.S. in Chemical Engineering, Georgia Institute of Technology, 2001

Publications

  • Rice JJ, Martino MM, Scott EA, Hubbell JA (2014). Controlled Release Strategies in Tissue Engineering. In C. Van Blitterswijk, & J. De Boer, Tissue Engineering (pp. 347-392). Waltham, MA: Academic Press.
  • Martino* MM, Briquez* PS, Güç E, Tortelli F, Kilarski WW, Metzger S, Rice JJ , Kuhn GA, Müller R, Swartz MA, and Hubbell JA (2014). Growth Factors Engineered for Super-affinity to Extracellular Matrix Enhance Tissue Healing. Science. 343(6173), 885-888.
  • De Laporte* L, Rice* JJ, Martino MM and Hubbell JA (2013). A fibronectin type III repeat that functions as a promiscuous growth factor binding domain. PLoS ONE 8(4): e62076.
  • Rice* JJ, Martino* MM, De Laporte* L, Tortelli* F, Briquez PS, Hubbell JA (2012). Engineering the regenerative microenvironment with biomaterials. Adv. Healthcare Materials, doi:10.1002 /adhm. 201200197.
  • Rice JJ, Gerwins P, and Kilarski WW (2012). Mechanisms of angiogenesis: Perspectives from antiangiogenic tumor therapies. Current Angiogenesis. 1(2):139-147.
  • Getz JA, Rice JJ and Daugherty PS (2011). Protease-resistant peptide ligands from a knottin scaffold library. ACS Chemical Biology. 6(8):837-44.
  • Rice JJ and Daugherty PS (2008). Directed evolution of a biterminal bacterial display scaffold enhances the display of diverse peptides and proteins. Protein Engineering Design and Selection. 21(7):435-42.
  • Kenrick SA, Rice JJ and Daugherty PS (2007). Flow cytometric sorting of bacterial surface-displayed libraries. Curren Protocols in Cytometry. Chapter 4, Unit 4.6.
  • Rice JJ, Schohn A, Bessette PH and Daugherty PS (2006). Bacterial display using circularly permuted outer membrane protein OmpX yields high affinity peptide ligands. Protein Science. 15(4):825-36.
  • Dane KY, Chan L, Rice JJ and Daugherty PS (2006). Isolation of cell specific peptide ligands using fluorescent bacterial display libraries. Journal of Immunological Methods. 309(1-2):120-9.
  • Bessette PH, Rice JJ and Daugherty PS (2004). Rapid isolation of high-affinity protein binding peptides using bacterial display. Protein Engineering Design and Selection. 17(10):731-9.

*authors contributed equally


Patents

  • Hubbell JA, Martino MM, De Laporte L, Rice JJ, Tortelli F. (To EPFL-TTO, Lausanne) Extracellular matrix heparin-binding domains. U.S. Patent Application 13/933,448, filed January 9, 2014. dfasdfdsaf
  • Daugherty, P.S., Bessette, P.H., and Rice, J.J. (To the Regents of the University of California). Polypeptide display libraries and methods of making and using thereof . U.S. Patent 7,256,038, issued August 14, 2007.
  • Daugherty, P.S., Rice, J.J. (To the Regents of the University of California). Methods For Enhancing Bacterial Cell Display Of Proteins And Peptides. U.S. Patent Application 12/220,448, filed July 24, 2008.
  • Hennessy, K.M., Rice, J.J. (To Applera Corporation). Methods, Compositions, And Kits For Quantitating Antibodies. U.S. Patent Application 11/743,052, filed May 1, 2007.